A Cytotoxic Substance from Sangre de Grado

Hideji ITOKAWA; Yoshitatsu ICHIHARA; Miwako MOCHIZUKI; Tamami ENOMORI; Hiroshi MORITA; Osamu SHIROTA; Mutsumi INAMATSU; Koichi TAKEYA

doi:10.1248/cpb.39.1041

Hideji ITOKAWA, Yoshitatsu ICHIHARA, Miwako MOCHIZUKI, Tamami ENOMORI, Hiroshi MORITA, Osamu SHIROTA, Mutsumi INAMATSU, Koichi TAKEYA

Author information

Keywords: Sangre de Grado, Croton palanostigma, Euphorbiaceae, taspine, alkaloid, cytotoxicity, V-79 cell, KB cell

JOURNAL FREE ACCESS

1991 Volume 39 Issue 4 Pages 1041-1042

DOI https://doi.org/10.1248/cpb.39.1041

Details

Abstract

Taspine has been isolated as a cytotoxic substance from Sangre de Grado, sap of Croton palanostigma (Euphorbiaceae), by bioassay guided fractionation. The cytotoxicity (IC₅₀) of taspine was found to be 0.39 μg/ml against KB cells and 0.17 μg/ml against V-79 cells.

Corresponding author

Register with J-STAGE for free!