Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
NOVEL REDUCTION OF CARBOXYLIC ACID, ESTER, AMIDE AND NITRILE WITH SAMARIUM OR YTTERIBIUM METAL-HYDROCHLORIC ACID SYSTEM
Yasuko KAMOCHITadahiro KUDO
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JOURNAL FREE ACCESS

1994 Volume 42 Issue 2 Pages 402-404

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Abstract

The reduction of organic functionalities with a samarium or ytteribium metal-hydrochloric acid system was investigated. Carboxylic acid, ester, amide and nitrile were rapidly reduced to the corresponding alcohol or primary amine with samarium or ytteribium metal in the presence of hydrochloric acid at room temperature under an argon atmosphere in good yields. Carboxylic acid was similarly reduced to alcohol with a magnesium or yttrium-hydrochloric acid system.

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© The Pharmaceutical Society of Japan
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