1999 Volume 47 Issue 7 Pages 1020-1023
Potent new biocides against both bacteria and fungi, 4, 4'-(1, 6-hexamethylenedioxydicarbonyl)bis(1-alkylpyridinium iodide)s (4DOCBP-6, n) (alkyl chain length, n=8, 10, 12, 14, 16 and 18) were synthesized. 4DOCBP-6, n is bis-quaternary ammonium compound (bis-QAC) and has a symmetrical dimeric structure which is composed of two alkylpyridinium iodides connected with a hexamethylenedioxydicarbonyl chain. 4DOCBP-6, 10 and 4DOCBP-6, 12 exhibited wide and effective antimicrobial spectra, compared with those of typical bactericides, N-dodecylpyridinium iodides (P-12) and benzyldimethyldodecylammonium chloride (BAC), or a popularly-used fungicide, 2-(4-thiazolyl)benzimidazole (TBZ). Their superior properties would be due to the unique dimeric structure which contains two active moieties in a molecule.