Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Synthesis and Antimicrobial Characteristics of Novel Biocides, 4, 4'-(1, 6-Hexamethylenedioxydicarbonyl)bis(1-alkylpyridinium iodide)s
Takuya MAEDAYuki MANABEMasashi YAMAMOTOMunehiro YOSHIDAKiyo OKAZAKIHideaki NAGAMUNEHiroki KOURAI
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1999 Volume 47 Issue 7 Pages 1020-1023

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Abstract

Potent new biocides against both bacteria and fungi, 4, 4'-(1, 6-hexamethylenedioxydicarbonyl)bis(1-alkylpyridinium iodide)s (4DOCBP-6, n) (alkyl chain length, n=8, 10, 12, 14, 16 and 18) were synthesized. 4DOCBP-6, n is bis-quaternary ammonium compound (bis-QAC) and has a symmetrical dimeric structure which is composed of two alkylpyridinium iodides connected with a hexamethylenedioxydicarbonyl chain. 4DOCBP-6, 10 and 4DOCBP-6, 12 exhibited wide and effective antimicrobial spectra, compared with those of typical bactericides, N-dodecylpyridinium iodides (P-12) and benzyldimethyldodecylammonium chloride (BAC), or a popularly-used fungicide, 2-(4-thiazolyl)benzimidazole (TBZ). Their superior properties would be due to the unique dimeric structure which contains two active moieties in a molecule.

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© The Pharmaceutical Society of Japan
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