Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
ISSN-L : 0386-7196
REVIEW
Role of ETS Family Transcription Factors in Vascular Development and Angiogenesis
Yasufumi Sato
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JOURNAL FREE ACCESS

2001 Volume 26 Issue 1 Pages 19-24

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Abstract

The ETS family of transcription factors is defined by a conserved DNA-binding ETS domain that forms a winged helix-turn-helix structural motif. This family of transcription factors is involved in a diverse array of biological functions including cellular growth and differentiation, as well as organ development. Among the members of this family, ETS-1, ERG, Fli-1, TEL, and NERF-2 are expressed in endothelial cells and their progenitors. This review will summarize the role of ETS family transcription factors in vascular development and angiogenesis.

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© 2001 by Japan Society for Cell Biology
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