日本骨髄バンクドナーの2回骨髄提供に関する検討

折原 勝己; 吾郷 浩厚; 奥山 美樹; 落合 亮一; 澤 正史; 田野﨑 隆二; 玉井 佳子; 豊嶋 崇徳; 中尾 康夫; 日野 雅之; 宮﨑 泰司; 神田 善伸; 金森 平和

doi:10.7889/hct.6.108

Original Article

Study of twice marrow donations from unrelated donors in Japan Marrow Donor Program

Katsumi Orihara, Hiroatu Ago, Yoshiki Okuyama, Ryoichi Ochiai, Masashi Sawa, Ryuji Tanosaki, Yoshiko Tamai, Takanori Teshima, Yasuo Nakao, Masayuki Hino, Yasushi Miyazaki, Yoshinobu Kanda, Heiwa Kanamori

Author information

Katsumi Orihara
Donor Coordination Department, Japan Marrow Donor Program
Hiroatu Ago
Department of Hematology and Oncology, Shimane Prefectural Central Hospital
Donor Safety Committee, Japan Marrow Donor Program
Yoshiki Okuyama
Department of Transfusion and Cell Therapy, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
Donor Safety Committee, Japan Marrow Donor Program
Ryoichi Ochiai
Department of anesthesiology, Toho University Omori Medical Center
Donor Safety Committee, Japan Marrow Donor Program
Masashi Sawa
Department of Hematology and Oncology, Anjo Kosei Hospital
Donor Safety Committee, Japan Marrow Donor Program
Ryuji Tanosaki
Center for Transfusion Medicine and Cell Therapy, Keio University School of Medicine
Donor Safety Committee, Japan Marrow Donor Program
Yoshiko Tamai
Department of Transfusion Medicine, Hirosaki University Hospital
Donor Safety Committee, Japan Marrow Donor Program
Takanori Teshima
Department of Hematology, Hokkaido University Graduate School of Medicine
Donor Safety Committee, Japan Marrow Donor Program
Yasuo Nakao
Department of anesthesiology, Sapporo Hokuyu Hospital
Donor Safety Committee, Japan Marrow Donor Program
Masayuki Hino
Department of Hematology, Osaka City University Graduate School of Medicine
Donor Safety Committee, Japan Marrow Donor Program
Yasushi Miyazaki
Atomic Bomb Disease Institute, Nagasaki University
Donor Safety Committee, Japan Marrow Donor Program
Yoshinobu Kanda
Division of Hematology, Saitama Medical Center, Jichi Medical University
Heiwa Kanamori
Department of Hematology, Kanagawa Cancer Center
Donor Safety Committee, Japan Marrow Donor Program

Keywords: unrelated donor, second bone marrow donation

JOURNAL FREE ACCESS

2017 Volume 6 Issue 2 Pages 108-114

DOI https://doi.org/10.7889/hct.6.108

Details

Abstract

We studied the influence of second marrow donation from Japan Marrow Donor Program on donor’s physical loads and transplant outcomes. Eight hundred and twenty donors were available. The duration between first and second donation was about 4 years. The shorter term of coordination was confirmed in second donation compared to first donation. The duration of pain and recovery to daily life in second donation were shorter than those in first donation, although the degree of pain was same in first and second donation. Harvesting time and volume of bone marrow, total cell count, cell concentration, and cell count/patient weight in first and second donation were 74 min: 78 min (P<0.001), 821 mL: 848 mL (P=0.095), 160×10⁸ cells: 139×10⁸ cells (P<0.001), 2.0×10⁷ cells/mL: 1.7×10⁷ cells/mL (P<0.001), and 3.0×10⁸ cells/kg: 2.7×10⁸ cells/kg (P<0.001), respectively. Delayed hematopoietic recovery and poor overall survival were observed in patients who received bone marrow transplantation from second donation. The results indicated that long-term influence is unclear, but second donation is permissible for voluntary donors. Further analysis will be necessary to clarify the impact of second marrow donation on transplant outcomes.

Corresponding author

Correction information

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