Six-Month Angiographic Study of Immediate Autologous Bone Marrow Mononuclear Cell Implantation on Acute Anterior Wall Myocardial Infarction Using a Mini-Pig Model

Jiunn-Jye Sheu; Chun-Man Yuen; Cheuk-Kwan Sun; Li-Teh Chang; Chia-Hung Yen; Chiang-Hua Chiang; Sheung-Fat Ko; Sung-Nan Pei; Sarah Chua; Anuj Bhasin; Chiung-Jen Wu; Hon-Kan Yip

doi:10.1536/ihj.50.221

Jiunn-Jye Sheu ^†, Chun-Man Yuen ^†, Cheuk-Kwan Sun ^†, Li-Teh Chang ^†, Chia-Hung Yen ^†, Chiang-Hua Chiang ^†, Sheung-Fat Ko ^†, Sung-Nan Pei ^†, Sarah Chua ^†, Anuj Bhasin ^†, Chiung-Jen Wu ^†, Hon-Kan Yip ^†

Author information

Jiunn-Jye Sheu ^†
Department of Cardiovascular Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
Chun-Man Yuen ^†
Department of Neurosurgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
Cheuk-Kwan Sun ^†
Department of General Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
Li-Teh Chang ^†
Basic Science, Nursing Department, Meiho Institute of Technology
Chia-Hung Yen ^†
Department of Life Science, National Pingtung University of Science and Technology
Chiang-Hua Chiang ^†
Department of Veterinary Medicine, National Pingtung University of Science and Technology
Sheung-Fat Ko ^†
Department of Radiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
Sung-Nan Pei ^†
Department of Hematology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
Sarah Chua ^†
Department of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
Anuj Bhasin ^†
Department of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
Chiung-Jen Wu ^†
Department of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
Hon-Kan Yip ^†
Department of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
Author contributions

†These authors contributed equally: Jiunn-Jye Sheu, Chun-Man Yuen, Cheuk-Kwan Sun, Li-Teh Chang, Chia-Hung Yen, Chiang-Hua Chiang, Sheung-Fat Ko, Sung-Nan Pei, Sarah Chua, Anuj Bhasin, Chiung-Jen Wu, Hon-Kan Yip

Keywords: Acute myocardial infarction, Bone-marrow cell transplantation, Mini-pig, Angiographic studies

JOURNAL FREE ACCESS

2009 Volume 50 Issue 2 Pages 221-234

DOI https://doi.org/10.1536/ihj.50.221

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Abstract

This study investigated six-month angiographic results of autologous bone marrow mononuclear cell (BMMNC) transplantation immediately following acute myocardial in-farction (AMI) in a mini-pig model.
AMI was induced by left anterior descending artery ligation. Twenty-four mini-pigs were equally divided into group 1 [AMI plus saline injection in infarcted area (IA)], group 2 (AMI plus BMMNC transplantation into non-IA), group 3 (AMI plus BMMNC implantation into IA), and group 4 (sham control). One-week cultured BMMNCs (3.0 × 10⁷) were immediately transplanted following AMI induction. Angiographic studies over 6 months demonstrated that mitral regurgitation (MR) was lower in groups 3 and 4 than in groups 1 and 2 (all P < 0.01). Wall motion scores and left ventricular ejection fraction (LVEF) were higher in groups 3 and 4 than in groups 1 and 2 (all P < 0.05). Collateral circulation was higher in group 3 than in groups 1 and 2 ( P < 0.01). The wall thickness of the IA was higher, whereas the heart weight was lower in group 3 than in groups 1 and 2 (all P < 0.01).
Immediate autologous BMMNC transplantation into IA is superior to saline-treated only or BMMNC transplantation into non-IA following AMI for reducing MR and improving LVEF.

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