Most of the pathophysiological actions of angiotensin II (Ang II) are mediated through the Ang II type 1 (AT₁) receptor, a member of the seven-transmembrane G protein-coupled receptor family. Essentially, AT₁ receptor signaling is beneficial for organismal survival and procreation, because it is crucial for normal organ development, and blood pressure and electrolyte homeostasis. On the other hand, AT₁ receptor signaling has detrimental effects, such as promoting various aging-related diseases that include cardiovascular diseases, diabetes, chronic kidney disease, dementia, osteoporosis, and cancer. Pharmacological or genetic blockade of AT₁ receptor signaling in rodents has been shown to prevent the progression of aging-related phenotypes and promote longevity. In this way, AT₁ receptor signaling exerts antagonistic and pleiotropic effects according to the ages and pathophysiological conditions. Here we review the pleiotropic effects of AT₁ receptor signaling in cardiovascular homeostasis and aging.