Utility of Cystatin C for Estimating Glomerular Filtration Rate in Patients With Muscular Dystrophy A Good Agreement With Inulin Clearance

Koichi Kimura; Hiroyuki Morita; Masao Daimon; Masaru Horio; Takayuki Kawata; Tomoko Nakao; Megumi Hirokawa; Ruriko Kitao; Daisuke Watanabe; Tetsuo Komori; Tetsuya Nagata; Shin’ichi Takeda; Hirofumi Komaki; Kazuhiko Segawa; Takashi Nakajima; Katsu Takenaka; Issei Komuro

doi:10.1536/ihj.15-461

Case Reports

Utility of Cystatin C for Estimating Glomerular Filtration Rate in Patients With Muscular Dystrophy

A Good Agreement With Inulin Clearance

Koichi Kimura, Hiroyuki Morita, Masao Daimon, Masaru Horio, Takayuki Kawata, Tomoko Nakao, Megumi Hirokawa, Ruriko Kitao, Daisuke Watanabe, Tetsuo Komori, Tetsuya Nagata, Shin’ichi Takeda, Hirofumi Komaki, Kazuhiko Segawa, Takashi Nakajima, Katsu Takenaka, Issei Komuro

Author information

Koichi Kimura
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
Hiroyuki Morita
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
Masao Daimon
Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo
Masaru Horio
Department of Functional Diagnostic Science, Graduate School of Medicine, Osaka University
Takayuki Kawata
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
Tomoko Nakao
Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo
Megumi Hirokawa
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
Ruriko Kitao
Department of Neurology, Hakone National Hospital
Daisuke Watanabe
Department of Neurology, Hakone National Hospital
Tetsuo Komori
Department of Neurology, Hakone National Hospital
Tetsuya Nagata
Department of Molecular Therapy, National Center of Neurology and Psychiatry
Shin’ichi Takeda
Department of Molecular Therapy, National Center of Neurology and Psychiatry
Hirofumi Komaki
Department of Child Neurology, National Center of Neurology and Psychiatry
Kazuhiko Segawa
Department of Cardiology, National Center of Neurology and Psychiatry
Takashi Nakajima
Department of Neurology, Niigata National Hospital
Katsu Takenaka
Nihon University Itabashi Hospital
Issei Komuro
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo

Keywords: Heart failure, Sudden death, Renal function, Creatinine, Inulin

JOURNAL FREE ACCESS

2016 Volume 57 Issue 3 Pages 386-388

DOI https://doi.org/10.1536/ihj.15-461

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Abstract

Emerging concerns regarding heart failure, arrhythmia, and sudden death in patients with muscular dystrophy are of significant clinical importance. On the other hand, little attention has been paid to renal dysfunction because these patients have low serum creatinine levels. Serum cystatin C, unaffected by muscle quantity, is a potentially superior marker for estimating renal function. Here, we present cases with muscular dystrophy in which estimated glomerular filtration rate (GFR) by cystatin C (eGFRcys) provided good agreement with simultaneously measured GFR by inulin renal clearance (differences less than 20%). Sudden death with acute heart failure occurred in a patient with underlying renal dysfunction and elevated BNP. Neurologists and cardiologists should evaluate renal function using GFR with cystatin C in patients with muscular dystrophy.

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