Churg-Strauss Syndrome Associated with Hypersensitivity to Acetaminophen

Aki MASUZAWA; Masato MORIGUCHI; Tokutaro TSUDA; Hitoshi SUGAWARA; Mieko OTSUKA; Shigeki YAMADA; Kaoru TABEI; Masanobu KAWAKAMI

doi:10.2169/internalmedicine.44.496

CASE REPORTS

Churg-Strauss Syndrome Associated with Hypersensitivity to Acetaminophen

Aki MASUZAWA, Masato MORIGUCHI, Tokutaro TSUDA, Hitoshi SUGAWARA, Mieko OTSUKA, Shigeki YAMADA, Kaoru TABEI, Masanobu KAWAKAMI

Author information

Aki MASUZAWA
Division of Integrated Medicine I, Omiya Medical Center, Jichi Medical School, Saitama
Masato MORIGUCHI
Division of Integrated Medicine I, Omiya Medical Center, Jichi Medical School, Saitama
Tokutaro TSUDA
Division of Integrated Medicine I, Omiya Medical Center, Jichi Medical School, Saitama
Hitoshi SUGAWARA
Division of Integrated Medicine I, Omiya Medical Center, Jichi Medical School, Saitama
Mieko OTSUKA
Division of Integrated Medicine I, Omiya Medical Center, Jichi Medical School, Saitama
Shigeki YAMADA
Division of Integrated Medicine I, Omiya Medical Center, Jichi Medical School, Saitama
Kaoru TABEI
Division of Integrated Medicine I, Omiya Medical Center, Jichi Medical School, Saitama
Masanobu KAWAKAMI
Division of Integrated Medicine I, Omiya Medical Center, Jichi Medical School, Saitama

Keywords: Churg-Strauss syndrome, acetaminophen, hypersensitivity, necrotizing vasculitis

JOURNAL OPEN ACCESS

2005 Volume 44 Issue 5 Pages 496-498

DOI https://doi.org/10.2169/internalmedicine.44.496

Details

Abstract

Acetaminophen is a widely used antipyretic drug. We describe a 64-year-old Japanese woman who developed typical Churg-Strauss syndrome after frequent use of acetaminophen. Following the ingestion of acetaminophen, she exhibited various allergic reactions such as asthmatic attacks, pyrexia and petechiae on legs. In the lymphocyte transformation test, a positive reaction to acetaminophen was detected. A muscle biopsy revealed massive extravascular eosinophil infiltration and a necrotizing vasculitis. Hypersensitivity to acetaminophen may be implicated in the development of Churg-Strauss syndrome in this case.

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