Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Type 2 Diabetes Mellitus Complicated with Smoldering Myeloma and Non-alcoholic Steatohepatitis
Takehiro NAKAHARA, Toshihiro UTSUGI, Yoshio OHYAMA, Shoichi TOMONO, Ken SATO, Hitoshi TAKAGI, Hirokazu MURAKAMI, Akira HASEGAWA, Masahiko KURABAYASHI
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Keywords: non-alcoholic steatohepatitis, diabetes mellitus, myeloma
JOURNAL OPEN ACCESS

2005 Volume 44 Issue 8 Pages 838-842

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Abstract

We report a 59-year-old woman with type 2 diabetes mellitus (DM) complicated with smoldering myeloma and non-alcoholic steatohepatitis. A diagnosis of smoldering myeloma was made on the basis of elevation of IgA, M-protein (type:IgA-λ) and histological findings of bone marrow without bone lesion. As to liver dysfunction, anti-HBV, anti-HCV and a series of auto-immune antibody were negative. She had no alcohol drinking habit and histological findings showed pericellular fibrosis without fatty degeneration, suggesting liver cirrhosis due to non-alcoholic steatohepatitis (NASH). To date, there are no reports of cases with DM, NASH and myeloma. Particular attention may be necessary for these complications.

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© 2005 by The Japanese Society of Internal Medicine
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