Pulmonary Relapse of Non-Hodgkin's Lymphoma in Bilateral Upper Lobes

Yoshiko Fujimoto; Kenichi Nomura; Daisuke Shimizu; Takashi Okuda; Naohisa Yoshida; Yosuke Matsumoto; Tomohiko Taki; Shigeo Horiike; Masafumi Taniwaki

doi:10.2169/internalmedicine.45.1636

CASE REPORTS

Pulmonary Relapse of Non-Hodgkin's Lymphoma in Bilateral Upper Lobes

Yoshiko Fujimoto, Kenichi Nomura, Daisuke Shimizu, Takashi Okuda, Naohisa Yoshida, Yosuke Matsumoto, Tomohiko Taki, Shigeo Horiike, Masafumi Taniwaki

Author information

Yoshiko Fujimoto
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Kenichi Nomura
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Daisuke Shimizu
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Department of Molecular Cytogenetics and Laboratory Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Takashi Okuda
Department of Molecular Cytogenetics and Laboratory Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Naohisa Yoshida
Department of Molecular Cytogenetics and Laboratory Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Yosuke Matsumoto
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Tomohiko Taki
Department of Molecular Cytogenetics and Laboratory Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Shigeo Horiike
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Masafumi Taniwaki
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
Department of Molecular Cytogenetics and Laboratory Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science

Keywords: bronchovascular-lymphangitis-like shadow, lymphoma, upper lung, trans-bronchial lung biopsy

JOURNAL OPEN ACCESS

2006 Volume 45 Issue 16 Pages 971-973

DOI https://doi.org/10.2169/internalmedicine.45.1636

Details

Abstract

We describe a 68-year-old male patient with diffuse large B-cell lymphoma (DLBCL) who suffered from relapse in bilateral upper lobes of the lung. The patient presented with cough, weakness and fever. A bronchovascular-lymphangitis-like shadow was detected in the bilateral upper lobes on a chest roentgenogram. Although cytological and cytofluorometric examinations revealed no malignant cells in the bronchoalveolar lavage fluid, trans-bronchial lung biopsy (TBLB) showed involvement of DLBCL in the bronchial mucosa. Recurrent lymphoma tends to extend along the bronchovascular bundles, resulting in granulomatous consolidation that may mimic tuberculosis and is likely to involve the lower lobes. Thus, TBLB proved to be essential for the diagnosis of the lung involvement of non-Hodgkin's lymphoma (NHL).

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