Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Cerebral Pachyleptomeningitis Associated with MPO-ANCA Induced by PTU Therapy
Takato AbeShigeru NogawaNorio TanahashiJunichi ShiraishiEiji IkedaNorihiro Suzuki
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JOURNAL OPEN ACCESS

2007 Volume 46 Issue 5 Pages 247-250

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Abstract

A 34-year-old woman with hyperthyroidism, who had been previously treated with propylthiouracil (PTU) is reported. She was admitted because of clumsiness in her left hand and abnormal behavior. A neurological examination demonstrated impairment of higher cortical function, and weakness and hyperreflexia of the left leg. An MRI scan with gadolinium enhancement showed pachyleptomeningeal thickening in the right frontoparietal lobe. Blood tests revealed a high MPO-ANCA titer of 122 EU (normal:<10 EU). After steroid administration, the neurological symptoms and the MRI findings improved markedly. This is the first report of PTU-induced cerebral pachyleptomeningitis associated with a high serum MPO-ANCA titer.

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© 2007 by The Japanese Society of Internal Medicine
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