Hypereosinophilia Associated with Increased Serum Levels of Carcinoembryonic Antigen

Hiroka Iwata; Nobuo Tsuboi; Takeo Ishii; Yoichiro Hara; Ichiro Okido; Hajime Takahashi; Tetsuya Kawamura; Tatsuo Hosoya

doi:10.2169/internalmedicine.47.0611

CASE REPORTS

Hypereosinophilia Associated with Increased Serum Levels of Carcinoembryonic Antigen

Hiroka Iwata, Nobuo Tsuboi, Takeo Ishii, Yoichiro Hara, Ichiro Okido, Hajime Takahashi, Tetsuya Kawamura, Tatsuo Hosoya

Author information

Hiroka Iwata
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine
Nobuo Tsuboi
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine
Takeo Ishii
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine
Yoichiro Hara
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine
Ichiro Okido
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine
Hajime Takahashi
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine
Tetsuya Kawamura
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine
Tatsuo Hosoya
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine

Keywords: eosinophilia, HES, CEA, corticosteroid

JOURNAL OPEN ACCESS

2008 Volume 47 Issue 10 Pages 963-967

DOI https://doi.org/10.2169/internalmedicine.47.0611

Details

Abstract

We report a case of hypereosinophilia associated with increased serum levels of carcinoembryonic antigen (CEA). The patient developed fever, diarrhea, erythroderma and eosinophilia. Disorders known to be associated with eosinophilia were not detected. The typical malignant diseases related to a rise in CEA levels were not identified. The CEA value reached a maximum of 81.4 ng/ml a few weeks late for the peak of the eosinophilic count. Corticosteroid therapy was effective in improving clinical symptoms and the CEA values decreased in association with the improvement of those manifestations, suggesting a pathophysiological link between the disease activity of hypereosinophilia and the changes in CEA level.

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