Improvement of Cardiac Function after Granulocyte-colony Stimulating Factor-mobilized Peripheral Blood Mononuclear Cell Implantation in a Patient with Non-ischemic Dilated Cardiomyopathy Associated with Thromboangiitis Obliterans

Ayano Kakihana; Akio Ishida; Megumi Miyagi; Tetsuya Ishiki; Koichiro Okumura; Tomomasa Kamiyama; Yusuke Ohya; Shuichi Takishita

doi:10.2169/internalmedicine.48.2117

CASE REPORTS

Improvement of Cardiac Function after Granulocyte-colony Stimulating Factor-mobilized Peripheral Blood Mononuclear Cell Implantation in a Patient with Non-ischemic Dilated Cardiomyopathy Associated with Thromboangiitis Obliterans

Ayano Kakihana, Akio Ishida, Megumi Miyagi, Tetsuya Ishiki, Koichiro Okumura, Tomomasa Kamiyama, Yusuke Ohya, Shuichi Takishita

Author information

Ayano Kakihana
Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine
Akio Ishida
Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine
Megumi Miyagi
Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine
Tetsuya Ishiki
Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine
Koichiro Okumura
Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine
Tomomasa Kamiyama
Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine
Yusuke Ohya
Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine
Shuichi Takishita
Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine

Keywords: peripheral blood mononuclear cell implantation, dilated cardiomyopathy, thromboangiitis obliterans, ¹²³I-metaiodobenzylguanidine, G-CSF

JOURNAL OPEN ACCESS

2009 Volume 48 Issue 12 Pages 1003-1007

DOI https://doi.org/10.2169/internalmedicine.48.2117

Details

Abstract

Cardiac involvement is a rare complication with thromboangiitis obliterans (TAO). We report a 29-year-old man with TAO accompanied with non-ischemic dilated cardiomyopathy. He had no history of heart disease, but echocardiogram demonstrated diffuse hypokinesis and dilated left ventricle. Coronary angiography revealed no organic stenotic lesion. For limb salvage, he was treated with granulocyte-colony stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cell (PBMNC) implantation on his right leg. Not only ischemic leg symptoms, but also plasma level of BNP and ¹²³I-metaiodobenzylguanidine scintigraphic parameters improved after 24 weeks. G-CSF-mobilized PBMNC implantation could be an effective approach to treating non-ischemic cardiomyopathy.

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