Light Chain Deposition Disease Developing 15 Years Following the Diagnosis of Monoclonal Gammopathy of Undetermined Significance

Takafumi Okura; Ken-ichi Miyoshi; Tomoaki Nagao; Masanori Jotoku; Daijiro Enomoto; Jun Irita; Mie Kurata; Jitsuo Higaki

doi:10.2169/internalmedicine.48.1679

CASE REPORTS

Light Chain Deposition Disease Developing 15 Years Following the Diagnosis of Monoclonal Gammopathy of Undetermined Significance

Takafumi Okura, Ken-ichi Miyoshi, Tomoaki Nagao, Masanori Jotoku, Daijiro Enomoto, Jun Irita, Mie Kurata, Jitsuo Higaki

Author information

Takafumi Okura
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
Ken-ichi Miyoshi
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
Tomoaki Nagao
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
Masanori Jotoku
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
Daijiro Enomoto
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
Jun Irita
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
Mie Kurata
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
Jitsuo Higaki
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine

Keywords: light chain deposition disease, monoclonal gammopathy of undetermined significance, nephrotic syndrome

JOURNAL OPEN ACCESS

2009 Volume 48 Issue 2 Pages 101-104

DOI https://doi.org/10.2169/internalmedicine.48.1679

Details

Abstract

A 64-year-old woman was admitted because of leg edema. Fifteen years previously she had been diagnosed with monoclonal gammopathy of undetermined significance (MGUS). Urinary immunoelectrophoresis demonstrated positivity for IgA kappa light chains. Bone marrow aspiration revealed a mild plasmacytosis. Her renal biopsy specimen revealed thickened basement membrane, mesangial cell proliferation and an increase in the mesangial matrix. Immunofluorescence studies showed the deposition of kappa light chains in the capillary wall and nodular lesions. These findings confirmed a diagnosis of light chain deposit disease (LCDD) with MGUS. The development of LCDD in patients with MGUS for fifteen years is very rare.

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