CD3- and CD4-Positive Plasmablastic Lymphoma: A Literature Review of Japanese Plasmablastic Lymphoma Cases

Yuhko Suzuki; Tsutomu Yoshida; Naoya Nakamura; Hirotoshi Kamata; Shouko Kotani; Manabu Ohsaka; Sabine Kajita; Koji Miyazaki; Shinichi Ohtani; Meijin Nakayama; Ryouichi Horie; Kazushige Hayakawa; Nozomi Niitsu; Masaaki Higashihara

doi:10.2169/internalmedicine.49.3164

CASE REPORTS

CD3- and CD4-Positive Plasmablastic Lymphoma: A Literature Review of Japanese Plasmablastic Lymphoma Cases

Yuhko Suzuki, Tsutomu Yoshida, Naoya Nakamura, Hirotoshi Kamata, Shouko Kotani, Manabu Ohsaka, Sabine Kajita, Koji Miyazaki, Shinichi Ohtani, Meijin Nakayama, Ryouichi Horie, Kazushige Hayakawa, Nozomi Niitsu, Masaaki Higashihara

Author information

Yuhko Suzuki
Department of Hematology, Kitasato University School of Medicine
Department of Transfusion and Cell Transplantation, Kitasato University School of Medicine
Tsutomu Yoshida
Department of Pathology, Kitasato University School of Medicine
Naoya Nakamura
Department of Pathology, Tokai University School of Medicine
Hirotoshi Kamata
Department of Hematology, Kitasato University School of Medicine
Shouko Kotani
Department of Radiology, Kitasato University School of Medicine
Manabu Ohsaka
Department of Hematology, Kitasato University School of Medicine
Sabine Kajita
Department of Pathology, Kitasato University School of Medicine
Koji Miyazaki
Department of Hematology, Kitasato University School of Medicine
Shinichi Ohtani
Department of Transfusion and Cell Transplantation, Kitasato University School of Medicine
Meijin Nakayama
Department of Otolaryngology, Kitasato University School of Medicine
Ryouichi Horie
Department of Hematology, Kitasato University School of Medicine
Kazushige Hayakawa
Department of Radiology, Kitasato University School of Medicine
Nozomi Niitsu
Department of Hematology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University
Masaaki Higashihara
Department of Hematology, Kitasato University School of Medicine

Keywords: plasmablastic lymphoma, Japanese, CD3

JOURNAL OPEN ACCESS

2010 Volume 49 Issue 16 Pages 1801-1805

DOI https://doi.org/10.2169/internalmedicine.49.3164

Details

Abstract

Plasmablastic lymphoma (PBL) is a very rare and recently-described subtype of diffuse large B-cell lymphoma. A maxillary tumor in an 84-year-old HIV-negative Japanese-man was referred. The biopsied specimen showed a diffuse proliferation of mature plasma cells, expressing CD3 (+), CD4 (+), CD20 (-), CD138 (+) and EBER (+) by immunohistochemistry. He was diagnosed as a plasmablastic lymphoma; radiation therapy (RT) was started, but the response to the RT was only a partial response. To our knowledge, this is the first report of a patient with PBL expressing CD3 and CD4.

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