Community-Acquired Methicillin-Resistant Staphylococcus aureus Meningitis Complicated by Cerebral Infarction. Role of Antibiotic Combination of Linezolid Plus Levofloxacin

Mario Fernández-Ruiz; Carlos Cervera; Cristina Pitart; Gloria Pérez; Ana del Río; José M. Miró; Francesc Marco; Asunción Moreno

doi:10.2169/internalmedicine.49.3942

CASE REPORTS

Community-Acquired Methicillin-Resistant Staphylococcus aureus Meningitis Complicated by Cerebral Infarction. Role of Antibiotic Combination of Linezolid Plus Levofloxacin

Mario Fernández-Ruiz, Carlos Cervera, Cristina Pitart, Gloria Pérez, Ana del Río, José M. Miró, Francesc Marco, Asunción Moreno

Author information

Mario Fernández-Ruiz
Department of Infectious Diseases, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona
Carlos Cervera
Department of Infectious Diseases, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona
Cristina Pitart
Department of Microbiology, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona
Gloria Pérez
Department of Infectious Diseases, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona
Ana del Río
Department of Infectious Diseases, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona
José M. Miró
Department of Infectious Diseases, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona
Francesc Marco
Department of Microbiology, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona
Asunción Moreno
Department of Infectious Diseases, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona

Keywords: community-acquired methicillin-resistant Staphylococcus aureus, levofloxacin, linezolid, meninigitis, stroke, treatment

JOURNAL OPEN ACCESS

2010 Volume 49 Issue 18 Pages 1971-1974

DOI https://doi.org/10.2169/internalmedicine.49.3942

Details

Abstract

The therapeutic options available for central nervous system (CNS) infections due to resistant Gram-positive cocci remain limited. We report an unusual case of community-acquired methicillin-resistant Staphylococcus aureus meningitis complicated by cerebral infarction in the middle cerebral artery territory in a previously healthy young male. After an initial vancomycin-based regimen, treatment was completed with a seven-week course of linezolid and levofloxacin. The potential role of such a combination and, particularly, linezolid as a first-line therapy in serious CNS infections is also discussed.

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