Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
ORIGINAL ARTICLES
Influence of Low-Grade Inflammation on Plasma B-type Natriuretic Peptide Levels
Terumasa Inoue, Makoto Kawai, Tokiko Nakane, Ayumi Nojiri, Kosuke Minai, Kimiaki Komukai, Takayuki Ogawa, Kenichi Hongo, Masato Matsushima, Michihiro Yoshimura
Author information
Keywords: heart failure, left ventricular end-systolic dimension, serum C-reactive protein and prognosis
JOURNAL OPEN ACCESS

2010 Volume 49 Issue 24 Pages 2659-2668

Details
Download PDF (1254K)
Download citation RIS

(compatible with EndNote, Reference Manager, ProCite, RefWorks)

BIB TEX

(compatible with BibDesk, LaTeX)

Text
How to download citation
Contact us
Abstract

Objective B-type natriuretic peptide (BNP) is a cardiac hormone. The results of previous in vitro studies suggest that neurohumoral factors, and not only hemodynamic factors, may cause BNP secretion. In this study, we examined the impact of serum C-reactive protein (CRP) levels on the relationship between echocardiographic parameters and plasma BNP levels in patients with cardiovascular diseases.
Methods and Patients The study population comprised 417 patients who visited our cardiovascular unit with a problem. Both blood sampling and echocardiography were performed within one month.
Results Multiple regression analysis showed that plasma BNP levels were negatively correlated with male gender, body mass index, and estimated glomerular filtration rate, and positively correlated with serum CRP levels and left ventricular end-systolic dimension (LVDs). The study population was divided into two groups based on the 75th percentile of the serum CRP levels. Single regression analysis showed that a regression line between LVDs and plasma BNP levels was steeper in the group of patients with CRP levels above the 75th percentile. Multiple regression analysis revealed that the interaction term (LVDs × CRP) was significant, which means LVDs had more impact on plasma BNP levels at higher CRP levels.
Conclusion Plasma BNP levels increased with respect to the severity of cardiac dysfunction and serum CRP levels, and should therefore be considered a collective or total marker for life-threatening conditions including systemic inflammation, and not simply as a marker of cardiac dysfunction in patients with cardiovascular diseases.

Content from these authors
© 2010 by The Japanese Society of Internal Medicine
Previous article Next article
Favorites & Alerts

Recently viewed articles
Predecessor

Japanese Journal of Medicine

Share this page
feedback
 Top