Endocardial Arrhythmogenic Mechanisms of Torsades de Pointes in Patients with the Congenital Long QT Syndrome

Masaomi Chinushi; Hiroshi Furushima; Yukio Hosaka; Satoru Komura; Akinori Sato; Kenichi Iijima; Yoshifusa Aizawa

doi:10.2169/internalmedicine.50.5114

CASE REPORTS

Endocardial Arrhythmogenic Mechanisms of Torsades de Pointes in Patients with the Congenital Long QT Syndrome

Masaomi Chinushi, Hiroshi Furushima, Yukio Hosaka, Satoru Komura, Akinori Sato, Kenichi Iijima, Yoshifusa Aizawa

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Keywords: Long QT syndrome, torsades de pointes, activation-recovery interval, repolarization dispersion

JOURNAL OPEN ACCESS

2011 Volume 50 Issue 16 Pages 1695-1702

DOI https://doi.org/10.2169/internalmedicine.50.5114

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Abstract

We injected acetylcholine (Ach) into the coronary artery to ascertain whether coronary vasospasm contributed to the syncopal events or chest oppression suffered by 3 patients with long QT syndrome (LQTS). During the test, a quadripolar electrode catheter was placed in the right ventricle and the activation-recovery interval was reanalyzed from the stored data. Intracoronary Ach transiently prolonged the QT intervals in all 3 patients without inducing coronary vasospasm. The Ach-induced QT prolongation was associated with enhanced spatial and temporal dispersion of intra-ventricular repolarization. The electrophysiological abnormalities were consistent with the putative arrhythmogenic mechanisms identified in experimental studies of LQTS.

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