A Case of Warfarin-induced Eosinophilia

Masakazu Teragaki; Hitomi Kawano; Ryojiro Makino; Keisuke Inoue; Yoshinori Sai; Mitsuharu Hosono; Shigefumi Suehiro; Mikio Okamura

doi:10.2169/internalmedicine.51.7138

CASE REPORTS

A Case of Warfarin-induced Eosinophilia

Masakazu Teragaki, Hitomi Kawano, Ryojiro Makino, Keisuke Inoue, Yoshinori Sai, Mitsuharu Hosono, Shigefumi Suehiro, Mikio Okamura

Author information

Masakazu Teragaki
Division of Cardiology, Department of Internal Medicine, Ohno Memorial Hospital, Japan
Hitomi Kawano
Division of Cardiology, Department of Internal Medicine, Ohno Memorial Hospital, Japan
Ryojiro Makino
Division of Nephrology, Department of Internal Medicine, Ohno Memorial Hospital, Japan
Keisuke Inoue
Division of Nephrology, Department of Internal Medicine, Ohno Memorial Hospital, Japan
Yoshinori Sai
Division of Nephrology, Department of Internal Medicine, Ohno Memorial Hospital, Japan
Mitsuharu Hosono
Department of Cardiovascular Surgery, Osaka City University, Japan
Shigefumi Suehiro
Department of Cardiovascular Surgery, Osaka City University, Japan
Mikio Okamura
Division of Nephrology, Department of Internal Medicine, Ohno Memorial Hospital, Japan

Keywords: Coumadin, anticoagulant therapy, eosinophilia, adverse effect

JOURNAL OPEN ACCESS

2012 Volume 51 Issue 12 Pages 1627-1629

DOI https://doi.org/10.2169/internalmedicine.51.7138

Details

Abstract

Warfarin is widely used in clinical practice all over the world. We report a man in whom prominent eosinophilia appeared after the initiation of warfarin administration following aortic valve replacement. Laboratory data following the administration and discontinuation of warfarin suggested that this drug was responsible for the eosinophilia. It is important to recognize the possibility of warfarin-induced hypereosinophilia as a latent adverse effect even when there are no clinical signs or symptoms.

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