Sai-rei-to-induced Lung Injury: A Case Report and Brief Review of the Literature

Kosaku Komiya; Hiroshi Ishii; Minoru Ohama; Masahiro Uchida; Tetsuo Tsubone; Tomohiko Iwashita; Hajime Miyajima; Eiji Okabe; Taisuke Matsumoto; Bunroku Matsumoto; Jun-ichi Kadota

doi:10.2169/internalmedicine.51.8705

CASE REPORTS

Sai-rei-to-induced Lung Injury: A Case Report and Brief Review of the Literature

Kosaku Komiya, Hiroshi Ishii, Minoru Ohama, Masahiro Uchida, Tetsuo Tsubone, Tomohiko Iwashita, Hajime Miyajima, Eiji Okabe, Taisuke Matsumoto, Bunroku Matsumoto, Jun-ichi Kadota

Author information

Kosaku Komiya
Department of Internal Medicine 2, Oita University Faculty of Medicine, Japan
Clinical Research Center of Respiratory Medicine, Tenshindo Hetsugi Hospital, Japan
Department of Internal Medicine, Tenshindo Hetsugi Hospital, Japan
Hiroshi Ishii
Department of Internal Medicine 2, Oita University Faculty of Medicine, Japan
Minoru Ohama
Department of Internal Medicine, Tenshindo Hetsugi Hospital, Japan
Masahiro Uchida
Department of Internal Medicine, Tenshindo Hetsugi Hospital, Japan
Tetsuo Tsubone
Department of Internal Medicine, Tenshindo Hetsugi Hospital, Japan
Tomohiko Iwashita
Department of Internal Medicine, Tenshindo Hetsugi Hospital, Japan
Hajime Miyajima
Department of Internal Medicine, Tenshindo Hetsugi Hospital, Japan
Eiji Okabe
Department of Internal Medicine, Tenshindo Hetsugi Hospital, Japan
Taisuke Matsumoto
Department of Internal Medicine, Tenshindo Hetsugi Hospital, Japan
Bunroku Matsumoto
Department of Internal Medicine, Tenshindo Hetsugi Hospital, Japan
Jun-ichi Kadota
Department of Internal Medicine 2, Oita University Faculty of Medicine, Japan

Keywords: Chinese herbal medicine, drug-induced lung injury, Sai-rei-to, Sho-saiko-to

JOURNAL OPEN ACCESS

2012 Volume 51 Issue 24 Pages 3421-3425

DOI https://doi.org/10.2169/internalmedicine.51.8705

Details

Abstract

An 81-year-old man was admitted to our hospital due to persistent fever and dyspnea with pulmonary infiltrates. He was treated successfully by discontinuing his current medications, including Sai-rei-to, and administering glucocorticoids. Drug lymphocyte stimulation tests showed a positive result for Sai-rei-to alone, and the resumption of other regular drugs did not re-induce the lung injury. Therefore, we diagnosed the patient with Sai-rei-to-induced lung injury. Sai-rei-to is a combination drug that consists of Sho-saiko-to and Gorei-san. This paper briefly reviews drug-induced lung injury caused by Sai-rei-to or its components with a case report.

Corresponding author

Register with J-STAGE for free!