Hashimoto's Thyroiditis Concomitant with Sequential Autoimmune Hepatitis, Chorea and Polyserositis: A New Entity of Autoimmune Polyendocrine Syndrome?

Internal Medicine

Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918

CASE REPORTS

Hashimoto's Thyroiditis Concomitant with Sequential Autoimmune Hepatitis, Chorea and Polyserositis: A New Entity of Autoimmune Polyendocrine Syndrome?

Haoyong Yu, Huiling Qiu, Jiemin Pan, Shenqi Wang, Yuqian Bao, Weiping Jia

Author information

Haoyong Yu
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, China
Huiling Qiu
Department of Osteoporosis, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, China
Jiemin Pan
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, China
Shenqi Wang
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, China
Yuqian Bao
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, China
Weiping Jia
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, China

Keywords: autoimmune polyglandular syndrome, Hashimoto's thyroiditis, autoimmune hepatitis, glucocorticoids

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 2 Pages 255-258

DOI https://doi.org/10.2169/internalmedicine.52.6799

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Abstract

We herein report a case of Hashimoto's thyroiditis (HT) with sequential autoimmune hepatitis (AIH), chorea and polyserositis. The patient was a 24-year-old man who underwent subtotal thyroidectomy due to compression symptoms caused by goiter and was diagnosed with HT postoperatively based on pathological examinations two years previously. He had exhibited liver dysfunction and intermittent chorea since 2008. His liver function and polyserositis improved remarkably following the administration of ursodeoxycholic acid (UDCA) and methylprednisolone. This is a very rare case that can be classified as autoimmune polyglandular syndrome (APS) type 3. Early and adequate UDCA and glucocorticoid treatment may lead to a favorable prognosis.

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© 2013 by The Japanese Society of Internal Medicine

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