IgG4-related Kidney Disease in Which the Urinalysis, Kidney Function and Imaging Findings Were Normal

Miho Otani; Masahiro Morinaga; Yoshihiko Nakajima; Hiromi Tomioka; Michiko Nishii; Yusuke Inoue; Tetsuya Ikeda; Mai Morimoto; Eiji Katsuyama; Shinichiro Tsunoda

doi:10.2169/internalmedicine.54.3259

CASE REPORTS

IgG4-related Kidney Disease in Which the Urinalysis, Kidney Function and Imaging Findings Were Normal

Miho Otani, Masahiro Morinaga, Yoshihiko Nakajima, Hiromi Tomioka, Michiko Nishii, Yusuke Inoue, Tetsuya Ikeda, Mai Morimoto, Eiji Katsuyama, Shinichiro Tsunoda

Author information

Miho Otani
Department of Nephrology, Kobe City Medical Center West Hospital, Japan
Masahiro Morinaga
Department of Nephrology, Kobe City Medical Center West Hospital, Japan
Yoshihiko Nakajima
Department of Nephrology, Kobe City Medical Center West Hospital, Japan
Hiromi Tomioka
Department of Respiratory Medicine, Kobe City Medical Center West Hospital, Japan
Michiko Nishii
Department of Dermatology, Kobe City Medical Center West Hospital, Japan
Yusuke Inoue
Department of Dermatology, Kobe City Medical Center West Hospital, Japan
Tetsuya Ikeda
Department of Dermatology, Kobe City Medical Center West Hospital, Japan
Mai Morimoto
Department of Rheumatology, Kobe City Medical Center West Hospital, Japan
Eiji Katsuyama
Department of Pathology, Kobe City Medical Center West Hospital, Japan
Shinichiro Tsunoda
Department of Rheumatology, Hyogo Medical University, Japan

Keywords: IgG4-related kidney disease, storiform fibrosis, interstitial nephritis

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 10 Pages 1253-1257

DOI https://doi.org/10.2169/internalmedicine.54.3259

Details

Abstract

IgG4-related kidney disease (IgG4RKD) is recognized as a fibroinflammatory disease characterized by storiform fibrosis, lymphoplasmacytic infiltration and a high serum IgG4 level. A renal biopsy is necessary to diagnose IgG4RKD in patients without any lesions in other organs. Nephrologists typically perform renal biopsies in patients with abnormal urinalysis, such as proteinuria or hematuria, or renal failure. However, we experienced a patient with IgG4RKD without abnormalities in the urinalysis, renal function or imaging, who had severe interstitial lesions. We therefore propose that renal biopsies should be considered if patients do not show abnormal urinalysis findings and are suspected to have IgG4RKD.

Corresponding author

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