Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Continuous Administration of Vancomycin through a Long Intestinal Tube for Clostridium difficile Infection
Naoto Mizumura, Koichi Demura, Masayasu Kawasaki, Satoshi Okumura, Sho Toyoda, Atsuo Imagawa, Masao Ogawa, Kazuki Ohba, Masao Kameyama
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Keywords: continuous administration, Clostridium difficile, vancomycin, long intestinal tube, maculopapular rash, systemic absorption
JOURNAL OPEN ACCESS

2015 Volume 54 Issue 12 Pages 1559-1562

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Abstract

A 76-year-old previously healthy Japanese man experienced severe diarrhea (8,000 mL per day) after undergoing laparotomy for small bowel obstruction and was diagnosed with Clostridium difficile infection. Although he developed a maculopapular rash secondary to the systemic absorption of enteral vancomycin (VCM), the patient was successfully treated with the continuous administration of VCM through a long intestinal tube placed in the terminal ileum. This method ensured the reliable delivery of VCM to the colon, while the continuous administration maintained high fecal levels of the drug. This treatment approach is an effective minimally invasive option for patients with severe diarrhea.

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© 2015 by The Japanese Society of Internal Medicine
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