A Comparison of Quantitative T2 Mapping on Cardiovascular Magnetic Resonance Imaging with Metaiodobenzylguanidine Scintigraphy and Left Ventricular Functional Recovery in Dilated Cardiomyopathy: A Retrospective Pilot Study

Tatsuro Ito; Atsushi K. Kono; Sachiko Takamine; Mayumi Shigeru; Shumpei Mori; Tomofumi Takaya; Sei Fujiwara; Tatsuya Nishii; Hideyuki Shiotani; Kazuro Sugimura; Ken-ichi Hirata

doi:10.2169/internalmedicine.54.4493

ORIGINAL ARTICLES

A Comparison of Quantitative T2 Mapping on Cardiovascular Magnetic Resonance Imaging with Metaiodobenzylguanidine Scintigraphy and Left Ventricular Functional Recovery in Dilated Cardiomyopathy: A Retrospective Pilot Study

Tatsuro Ito, Atsushi K. Kono, Sachiko Takamine, Mayumi Shigeru, Shumpei Mori, Tomofumi Takaya, Sei Fujiwara, Tatsuya Nishii, Hideyuki Shiotani, Kazuro Sugimura, Ken-ichi Hirata

Author information

Tatsuro Ito
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
Atsushi K. Kono
Department of Radiology, Kobe University Graduate School of Medicine, Japan
Sachiko Takamine
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
Mayumi Shigeru
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
Shumpei Mori
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
Tomofumi Takaya
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
Sei Fujiwara
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
Tatsuya Nishii
Department of Radiology, Kobe University Graduate School of Medicine, Japan
Hideyuki Shiotani
Kobe University Graduate School of Health Science, Japan
Kazuro Sugimura
Department of Radiology, Kobe University Graduate School of Medicine, Japan
Ken-ichi Hirata
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan

Keywords: dilated cardiomyopathy, functional recovery, magnetic resonance imaging, metaiodobenzylguanidine, T2 mapping

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 17 Pages 2121-2128

DOI https://doi.org/10.2169/internalmedicine.54.4493

Details

Abstract

Objective Metaiodobenzylguanidine (MIBG) scintigraphy is used to assess heart failure (HF) severity and to predict cardiac functional recovery. Cardiovascular magnetic resonance (CMR) imaging has recently been used to diagnosis HF. We evaluated CMR T2 mapping and MIBG scintigraphy in dilated cardiomyopathy (DCM) patients.
Methods Consecutively, 22 DCM patients [aged 56.8±13.4 years; 6 women and 16 men; left ventricular ejection fraction (LVEF), 31.9±10.7%] who underwent T2 mapping and MIBG scintigraphy were retrospectively evaluated. Echocardiography results were recorded at baseline and the 6-month follow-up. Patients with an increased LVEF ≥15% between the 2 measures were considered to be responders. We measured each patient's T2 values and MIBG indices [the heart-to-mediastinum ratio (H/M) in the early phase, H/M in the delayed phase, and the washout rate (WOR)] at baseline. We compared these values between the 12 responders and 10 non-responders.
Results The mean T2 value for all patients was 64.5±6.6 ms. The mean values of early H/M, delayed H/M, and WOR were 2.06±0.25, 1.94±0.35, and 43.5±11.8%, respectively. The T2 values were found to correlate with MIBG indices (p<0.05 for all) and were lower in the responders than non-responders (61.4 vs. 68.1 ms, p=0.013). MIBG indices were not significantly different.
Conclusion Our study shows that the T2 values correlated with the MIBG indices and were increased in non-responders. T2 mapping may be useful in assessing the cardiac function and functional recovery in DCM patients.

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