Diagnostic Challenges during Pretreatment Long-term Follow-up in a Patient with FIP1L1-PDGFRA-positive Eosinophilia

Danijela Lekovic; Andrija Bogdanovic; Maja Perunicic-Jovanovic; Gradimir Jankovic; Mirjana Gotic; Ivo Elezovic

doi:10.2169/internalmedicine.54.2258

CASE REPORTS

Diagnostic Challenges during Pretreatment Long-term Follow-up in a Patient with FIP1L1-PDGFRA-positive Eosinophilia

Danijela Lekovic, Andrija Bogdanovic, Maja Perunicic-Jovanovic, Gradimir Jankovic, Mirjana Gotic, Ivo Elezovic

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Keywords: eosinophilia, PDGFRA, imatinib

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 6 Pages 637-642

DOI https://doi.org/10.2169/internalmedicine.54.2258

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Abstract

Obtaining a precise characterization of eosinophilia is crucial, as successful treatment relies on the underlying etiology of the disease. Platelet-derived growth factor receptor alpha-related disorders were first specified in 2008 as a distinct group of clonal eosinophilic disorders with exceptional responsiveness to imatinib. We herein present the case of a man with myeloid neoplasm and eosinophilia in whom a definitive diagnosis could not be adequately made based on histopathological features who was ultimately diagnosed only after extensive molecular analyses and successfully treated with imatinib. In addition, we discuss the diagnostic and therapeutic approaches to treating patients presenting with eosinophilia.

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