Two Elderly Patients with Philadelphia Chromosome Positive Mixed Phenotype Acute Leukemia Who Were Successfully Treated with Dasatinib and Prednisolone

Hiroyuki Takata; Taichi Ikebe; Hitohiro Sasaki; Yasuhiko Miyazaki; Eiichi Ohtsuka; Yoshio Saburi; Masao Ogata; Kuniaki Shirao

doi:10.2169/internalmedicine.55.5223

CASE REPORTS

Two Elderly Patients with Philadelphia Chromosome Positive Mixed Phenotype Acute Leukemia Who Were Successfully Treated with Dasatinib and Prednisolone

Hiroyuki Takata, Taichi Ikebe, Hitohiro Sasaki, Yasuhiko Miyazaki, Eiichi Ohtsuka, Yoshio Saburi, Masao Ogata, Kuniaki Shirao

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Keywords: mixed phenotype acute leukemia, Philadelphia chromosome, dasatinib, prednisolone

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 9 Pages 1177-1181

DOI https://doi.org/10.2169/internalmedicine.55.5223

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Abstract

Philadelphia chromosome positive (Ph+) mixed phenotype acute leukemia (MPAL) is a rare type of acute leukemia having both myeloid and lymphoid features for which no optimal treatment has yet been established. We herein describe two elderly Ph+MPAL patients who achieved molecular remission without any serious adverse events by treatment with dasatinib and prednisolone. Although dasatinib induction therapy combined with prednisolone is known to be a highly effective treatment for Ph+ acute lymphoblastic leukemia, its efficacy for Ph+MPAL has not been shown. The clinical courses of the present cases suggest that combination therapy with dasatinib and prednisolone is a safe and effective therapeutic modality in elderly Ph+MPAL patients.

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