Drug-induced Liver Injury Associated with Mosapride Citrate: A Report of Two Cases

Ayaka Sako; Sung Kwan Bae; Toshifumi Gushima; Junichi Motoshita; Shigemune Bekki; Seigo Abiru; Atsumasa Komori; Shinji Shimoda; Masahiro Ito; Hiroshi Yatsuhashi; Kazuhiro Takahashi

doi:10.2169/internalmedicine.56.7374

CASE REPORTS

Drug-induced Liver Injury Associated with Mosapride Citrate: A Report of Two Cases

Ayaka Sako, Sung Kwan Bae, Toshifumi Gushima, Junichi Motoshita, Shigemune Bekki, Seigo Abiru, Atsumasa Komori, Shinji Shimoda, Masahiro Ito, Hiroshi Yatsuhashi, Kazuhiro Takahashi

Author information

Ayaka Sako
The Center for Liver Disease, Hamanomachi Hospital, Japan
Sung Kwan Bae
The Center for Liver Disease, Hamanomachi Hospital, Japan
Toshifumi Gushima
The Center for Liver Disease, Hamanomachi Hospital, Japan
Junichi Motoshita
Department of Pathology, Hamanomachi Hospital, Japan
Shigemune Bekki
Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Japan
Seigo Abiru
Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Japan
Atsumasa Komori
Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Japan
Shinji Shimoda
Medicine and Biosystemic Science, Kyushu University, Japan
Masahiro Ito
Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Japan
Hiroshi Yatsuhashi
Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Japan
Kazuhiro Takahashi
The Center for Liver Disease, Hamanomachi Hospital, Japan

Keywords: mosapride citrate, drug-induced liver injury, drug-induced lymphocyte stimulation test

JOURNAL OPEN ACCESS

2017 Volume 56 Issue 1 Pages 41-45

DOI https://doi.org/10.2169/internalmedicine.56.7374

Details

Abstract

We herein report two cases of drug-induced liver injury (DILI) due to mosapride. Case 1: A 78-year-old man was admitted with elevated transaminase levels. The cessation of mosapride led to the improvement of elevated liver enzyme levels. Case 2: A 54-year-old man was admitted with jaundice. Mosapride was discontinued immediately, and methylprednisolone was administered for acute liver failure. The patient's data showed improvement, and he was discharged on Day 32. In both cases, mosapride gave a positive response to a drug-induced lymphocyte stimulation test (DLST), and the patient's score based on the criteria for DILI was "highly probable".

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