Efficacy of Ivermectin against Strongyloides Stercoralis in Humans

Koushin SHIKIYA; Nagisa KINJO; Takeshi UEHARA; Hiroyuki UECHI; Junichi OHSHIRO; Tamiki ARAKAKI; Fukunori KINJO; Atsushi SAITO; Mamoru IJU; Kazumine KOBARI

doi:10.2169/internalmedicine.31.310

Efficacy of Ivermectin against Strongyloides Stercoralis in Humans

Koushin SHIKIYA, Nagisa KINJO, Takeshi UEHARA, Hiroyuki UECHI, Junichi OHSHIRO, Tamiki ARAKAKI, Fukunori KINJO, Atsushi SAITO, Mamoru IJU, Kazumine KOBARI

Author information

Koushin SHIKIYA
the First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
Nagisa KINJO
the First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
Takeshi UEHARA
the First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
Hiroyuki UECHI
the First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
Junichi OHSHIRO
the First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
Tamiki ARAKAKI
the First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
Fukunori KINJO
the First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
Atsushi SAITO
the First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
Mamoru IJU
the First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
Kazumine KOBARI
Ohama First Hospital

Keywords: Strongyloides stercoralis, ivermectin

JOURNAL FREE ACCESS

1992 Volume 31 Issue 3 Pages 310-312

DOI https://doi.org/10.2169/internalmedicine.31.310

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Abstract

Okinawa Prefecture is an endemic area of Strongyloides stercoralis infection. Since treatment of this infection remains unsatisfactory, we evaluated the efficacy of ivermectin. Twenty-three patients were treated with a single oral dose of ivermectin (mean±SD, 105.5±20.8 mcg/kg of body weight), followed by a second dose two weeks later. The rate of cure was 85.7% at 2 weeks after the first treatment, and 90.5% at 2 weeks after the second treatment. Side effects occurred in 2 patients (8.7%), but they were mild and transient. The results indicate that ivermectin might be useful and relatively safe for the therapy of Strongyloides stercoralis infection as an alternative to thiabendazole or mebendazole.
(Internal Medicine 31 : 310-312, 1992)

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