Familial Primary Hyperparathyroidism Complicated with Wilms' Tumor

Ayumu KAKINUMA; Isao MORIMOTO; Yoichiro NAKANO; Ryouji FUJIMOTO; Osamu ISHIDA; Yosuke OKADA; Nobuo INOKUCHI; Takashi FUJIHIRA; Sumiya ETO

doi:10.2169/internalmedicine.33.123

Ayumu KAKINUMA, Isao MORIMOTO, Yoichiro NAKANO, Ryouji FUJIMOTO, Osamu ISHIDA, Yosuke OKADA, Nobuo INOKUCHI, Takashi FUJIHIRA, Sumiya ETO

Author information

Ayumu KAKINUMA
The First Department of Internal Medicine, University of Occupational & Environmental Health
Isao MORIMOTO
The First Department of Internal Medicine, University of Occupational & Environmental Health
Yoichiro NAKANO
The First Department of Internal Medicine, University of Occupational & Environmental Health
Ryouji FUJIMOTO
The First Department of Internal Medicine, University of Occupational & Environmental Health
Osamu ISHIDA
The First Department of Internal Medicine, University of Occupational & Environmental Health
Yosuke OKADA
The First Department of Internal Medicine, University of Occupational & Environmental Health
Nobuo INOKUCHI
The First Department of Internal Medicine, University of Occupational & Environmental Health
Takashi FUJIHIRA
The First Department of Internal Medicine, University of Occupational & Environmental Health
Sumiya ETO
The First Department of Internal Medicine, University of Occupational & Environmental Health

Keywords: multiple endocrine neoplasia, MEN, parathyroid cancer, cementifying jaw fibroma, parathyroid hormone

JOURNAL FREE ACCESS

1994 Volume 33 Issue 2 Pages 123-126

DOI https://doi.org/10.2169/internalmedicine.33.123

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Abstract

We describe a familial occurrence of primary hyperparathyroidism. The proband is a 60-yearold woman who had a parathyroid adenoma. Her older sister had a parathyroid adenoma with cementifying jaw fibroma and her younger sister died of parathyroid adenocarcinoma with pulmonary metastasis at the age of 38. We have not yet obtained evidence for other endocrine disorders suggesting multiple endocrine neoplasia (MEN) in this pedigree. The proband is complicated with Wilms' tumor. It is now widely accepted that respective predisposed genes of MEN type 1 and Wilms' tumor, and PTH gene are located on chromosome 11. The manifestation observed in this case may be related to mutational abnormalities on chromosome 11.
(Internal Medicine 33:123-126, 1994)

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