Systemic Capillary Leak Syndrome Associated with Multiple Myeloma of IgG κType

Eiji HIRAOKA; Yumi MATSUSHIMA; Yoko INOMOTO-NARIBAYASHI; Hirohisa NAKATA; Akira NAKAMURA; Chiharu KAWANAMI; Yoshikazu KINOSHITA; Takashi ISOBE; Tsutomu CHIBA

doi:10.2169/internalmedicine.34.1220

Eiji HIRAOKA, Yumi MATSUSHIMA, Yoko INOMOTO-NARIBAYASHI, Hirohisa NAKATA, Akira NAKAMURA, Chiharu KAWANAMI, Yoshikazu KINOSHITA, Takashi ISOBE, Tsutomu CHIBA

Author information

Eiji HIRAOKA
the Division of Gerontology, the Department of Internal Medicine, Kobe University School of Medicine
Yumi MATSUSHIMA
the Division of Gerontology, the Department of Internal Medicine, Kobe University School of Medicine
Yoko INOMOTO-NARIBAYASHI
the Division of Gerontology, the Department of Internal Medicine, Kobe University School of Medicine
Hirohisa NAKATA
the Division of Gerontology, the Department of Internal Medicine, Kobe University School of Medicine
Akira NAKAMURA
the Division of Gerontology, the Department of Internal Medicine, Kobe University School of Medicine
Chiharu KAWANAMI
the Division of Gerontology, the Department of Internal Medicine, Kobe University School of Medicine
Yoshikazu KINOSHITA
the Division of Gerontology, the Department of Internal Medicine, Kobe University School of Medicine
Takashi ISOBE
the Division of Gerontology, the Department of Internal Medicine, Kobe University School of Medicine
Tsutomu CHIBA
the Division of Gerontology, the Department of Internal Medicine, Kobe University School of Medicine

Keywords: capillary hyperpermeability, monoclonal gammopathy

JOURNAL FREE ACCESS

1995 Volume 34 Issue 12 Pages 1220-1224

DOI https://doi.org/10.2169/internalmedicine.34.1220

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Abstract

A case of systemic capillary leak syndrome in a 67-year-old woman is reported. The patient suddenly presented with severe edema and hypotension associated with an increased hematocrit and a decreased level of serum albumin, suggesting capillary hyperpermeability. The patient had IgG κ monoclonal gammopathy in association with not only a slight increase in plasma cells in the bone marrow but also several punched out lesions in the skull, indicating multiple myeloma. Although most of the cases of systemic capillary leak syndrome reported previously were accompanied by monoclonal gammopathy, this appears to be the first case in which capillary leak syndrome developed in a patient with multiple myeloma.
(Internal Medicine 34: 1220-1224, 1995)

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