Polymorphisms of Apolipoprotein E and Methylenetetrahydrofolate Reductase in the Japanese Population

Hidenori Arai; Akira Yamamoto; Yuji Matsuzawa; Yasushi Saito; Nobuhiro Yamada; Shinichi Oikawa; Hiroshi Mabuchi; Tamio Teramoto; Jun Sasaki; Noriaki Nakaya; Hiroshige Itakura; Yuichi Ishikawa; Yasuyoshi Ouchi; Hiroshi Horibe; Tohru Egashira; Hiroaki Hattori; Toru Kita

doi:10.5551/jat.E499

Original Articles

Polymorphisms of Apolipoprotein E and Methylenetetrahydrofolate Reductase in the Japanese Population

Hidenori Arai, Akira Yamamoto, Yuji Matsuzawa, Yasushi Saito, Nobuhiro Yamada, Shinichi Oikawa, Hiroshi Mabuchi, Tamio Teramoto, Jun Sasaki, Noriaki Nakaya, Hiroshige Itakura, Yuichi Ishikawa, Yasuyoshi Ouchi, Hiroshi Horibe, Tohru Egashira, Hiroaki Hattori, Toru Kita

Author information

Hidenori Arai
Department of Geriatric Medicine, Kyoto University Graduate School of Medicine
Akira Yamamoto
National Cardiovascular Center
Yuji Matsuzawa
Sumitomo Hospital
Yasushi Saito
Department of Clinical Cell Biology and Medicine, Chiba University
Nobuhiro Yamada
Department of Internal Medicine, University of Tsukuba
Shinichi Oikawa
Department of Internal Medicine, Nippon Medical School
Hiroshi Mabuchi
Department of Laboratory Science, Kanazawa University
Tamio Teramoto
Department of Internal Medicine, Teikyo University
Jun Sasaki
International University of Health and Welfare
Noriaki Nakaya
Fussa Hospital
Hiroshige Itakura
Ibaraki Christian University
Yuichi Ishikawa
Faculty of Health Sciences, Kobe University
Yasuyoshi Ouchi
Department of Geriatric Medicine, University of Tokyo
Hiroshi Horibe
Keisen Clinic
Tohru Egashira
Department of Advanced Technology and Development, BML, Inc.
Hiroaki Hattori
Department of Advanced Technology and Development, BML, Inc.
Toru Kita
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine

Keywords: Hyperlipidemia, Polymorphism, Apolipoprotein E, MTHFR, Homocysteine

JOURNAL OPEN ACCESS

2007 Volume 14 Issue 4 Pages 167-171

DOI https://doi.org/10.5551/jat.E499

View "Advance Publication" version (August 14, 2007).

Details

Abstract

Aim: The aim of this study is to analyze the effect of apolipoprotein E (apo E) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms on serum lipid and homocysteine levels in the general Japanese population.
Methods: We analyzed the polymorphisms in individuals randomly selected from among participants of Serum Lipid Survey 2000.
Results: The frequency of the ε2, ε3, and ε4 alleles of APOE was 4.2, 85.3, and 10.5%, respectively. Individuals with the genotype ε4/ε4 had the highest total and low-density lipoprotein (LDL) cholesterol levels, while those with ε2/ε2 had the lowest. Individuals with the ε2/ε2 and ε2/ε4 genotypes had higher remnant-like particles (RLP)-cholesterol levels than those with ε2ε3, ε3ε3, and ε3ε4. There was a trend for individuals with the ε2/ε4 and ε2/ε2 genotypes to have higher triglyceride levels, although the difference was not significant. The presence of the T allele in a MTHFR polymorphism (C667T) was associated with higher homocysteine levels, which is more prominent in men than in women.
Conclusion: Thus in our large-scale analysis we have shown that RLP-cholesterol is better associated with, APOE genotype than triglyceride and the effect of the T allele on MTHFR polymorphism (C667T) homocysteine levels is more prominent in men than in women among Japanese.

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