Changes in Weight, Cardiovascular Risk Factors and Estimated Risk of Coronary Heart Disease Following Smoking Cessation in Japanese Male Workers: HIPOP-OHP Study

Unai Tamura; Taichiro Tanaka; Tomonori Okamura; Takashi Kadowaki; Hiroshi Yamato; Hideo Tanaka; Masakazu Nakamura; Akira Okayama; Hirotsugu Ueshima; Zentaro Yamagata; HIPOP-OHP research group HIPOP-OHP research group

doi:10.5551/jat.1800

Unai Tamura, Taichiro Tanaka, Tomonori Okamura, Takashi Kadowaki, Hiroshi Yamato, Hideo Tanaka, Masakazu Nakamura, Akira Okayama, Hirotsugu Ueshima, Zentaro Yamagata, HIPOP-OHP research group HIPOP-OHP research group

Author information

Unai Tamura
Department of Health Sciences, School of Medicine, University of Yamanashi.
Taichiro Tanaka
Department of Health Sciences, School of Medicine, University of Yamanashi.
Tomonori Okamura
Department of Preventive Cardiology, National Cardiovascular Center.
Takashi Kadowaki
Department of Health Science, Shiga University of Medical Science.
Hiroshi Yamato
Department of Health Development, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health.
Hideo Tanaka
Division of Epidemiology and Prevention, Aichi Cancer Center Hospital and Research Institute.
Masakazu Nakamura
Department of Health Promotion and Education, Osaka Medical Center for Health Science and Promotion.
Akira Okayama
The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association.
Hirotsugu Ueshima
Department of Health Science, Shiga University of Medical Science.
Zentaro Yamagata
Department of Health Sciences, School of Medicine, University of Yamanashi.
HIPOP-OHP research group HIPOP-OHP research group
Investigators and members of the research group are listed in Appendix A

Keywords: Lifestyle modification, Blood pressure, Cholesterol, Cardiovascular disease, Smoking cessation

JOURNAL OPEN ACCESS

2010 Volume 17 Issue 1 Pages 12-20

DOI https://doi.org/10.5551/jat.1800

View "Advance Publication" version (January 16, 2010).

Details

Abstract

Aim: It is well established that people gain weight after smoking cessation; however, changes in cardiovascular risk factors and the estimated risk of coronary heart disease following smoking cessation have yet to be fully clarified.
Methods: The participants were 1,995 Japanese male workers at 11 workplaces who participated continuously in the High-risk and Population Strategy for Occupational Health Promotion (HIPOPOHP) study. Participants with a smoking habit had cardiovascular risk factors measured at baseline and over a 4-yr period. Their estimated incidence risk of coronary heart disease was calculated by a formula based on a previous cohort study.
Results: Successful abstainers who had stopped smoking for at least 6 months at the end of the follow-up period had weight gains of approximately 2 kg. These subjects had significant worsening of the following factors compared to continuing smokers: systolic and diastolic blood pressure, total cholesterol, triglyceride and fasting blood sugar levels. In contrast, HDL-cholesterol levels improved significantly. When the overall instantaneous incidence risk of coronary heart disease prior to smoking cessation was assumed to be 1.00, the estimated risk was 0.76 (95%CI: 0.68-0.85) in successful abstainers due mainly to smoking cessation, despite weight gain.
Conclusion: Although smoking cessation leads to weight gain, the estimated risk of coronary heart disease was decreased markedly by smoking cessation.

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