ACE Inhibitory Activity and Characteristics of Tri-Peptides Obtained from Bonito Protein

Md. Fida Hasan; Yuka Kobayashi; Yoichi Kumada; Tomohisa Katsuda; Masaaki Terashima; Shigeo Katoh

doi:10.1252/jcej.40.59

Biochemical, Food and Medical Engineering

ACE Inhibitory Activity and Characteristics of Tri-Peptides Obtained from Bonito Protein

Md. Fida Hasan, Yuka Kobayashi, Yoichi Kumada, Tomohisa Katsuda, Masaaki Terashima, Shigeo Katoh

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Keywords: Angiotensin-I Converting Enzyme, Inhibitory Peptide, Competitive Inhibitor, Digestion, Bonito Protein

JOURNAL RESTRICTED ACCESS

2007 Volume 40 Issue 1 Pages 59-62

DOI https://doi.org/10.1252/jcej.40.59

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Abstract

Inhibition characteristics of tri-peptides IKW and IKY, which were obtained as angiotensin-I converting enzyme inhibitors from bonito protein, and their stability in digestive canal were studied. These IKW and IKY showed high inhibitory activities with IC₅₀ of 0.4 and 1.0 μM, respectively, and acted as competitive inhibitors. The tri-peptides, especially IKY, were very stable under simulated gastrointestinal digestion conditions.

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