Ca2+-Independent Phospholipase A2 Inhibitor Impairs Spatial Memory of Mice

Shinichi Fujita; Yuji Ikegaya; Nobuyoshi Nishiyama; Norio Matsuki

doi:10.1254/jjp.83.277

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Ca²⁺-Independent Phospholipase A₂ Inhibitor Impairs Spatial Memory of Mice

Shinichi Fujita, Yuji Ikegaya, Nobuyoshi Nishiyama, Norio Matsuki

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Keywords: Phospholipase A₂, Learning and memory, Spontaneous alternation behavior

JOURNAL FREE ACCESS

2000 Volume 83 Issue 3 Pages 277-278

DOI https://doi.org/10.1254/jjp.83.277

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Abstract

Pharmacological blockade of Ca²⁺−independent phospholipase A₂(PLA₂)is reported to disintegrate hippocampal synaptic plasticity, which is thought to be the cellular mechanism underlying learning and memory.Therefore, we investigated the effect of the Ca²⁺−independent PLA₂ inhibitor bromoenol lactone(BEL)on spontaneous alteration behaviors of mice.When 3 nmol BEL was intracerebroventricularly injected 30 min prior to the test, the mice showed a poor alternation ratio, compared with control animals.The data suggest that Ca²⁺−independent PLA₂ activity is required for spatial memory.

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