A Nuclear Factor-κB Inhibitor BAY 11-7082 Suppresses Endothelin-1 Production in Cultured Vascular Endothelial Cells

Mamoru Ohkita; Masanori Takaoka; Yasuko Shiota; Rumi Nojiri; Masato Sugii; Yasuo Matsumura

doi:10.1254/jjp.89.81

Short Communications

A Nuclear Factor-κB Inhibitor BAY 11-7082 Suppresses Endothelin-1 Production in Cultured Vascular Endothelial Cells

Mamoru Ohkita, Masanori Takaoka, Yasuko Shiota, Rumi Nojiri, Masato Sugii, Yasuo Matsumura

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Keywords: Nuclear factor-κB, Endothelin-1, Tumor necrosis factor-α

JOURNAL FREE ACCESS

2002 Volume 89 Issue 1 Pages 81-84

DOI https://doi.org/10.1254/jjp.89.81

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Abstract

BAY 11-7082, an inhibitor of nuclear factor-κB (NF-κB), which prevents a step of the phosphorylation of inhibitory protein IκB bound to NF-κB, suppressed basal and tumor necrosis factor (TNF)-α-induced prepro endothelin (ET)-1 mRNA expression and NF-κB activation in cultured vascular endothelial cells. BAY 11-7082 significantly decreased basal and TNF-α-induced ET-1 release from endothelial cells. These results indicate that the inhibition of NF-κB activation contributes to the suppressive effect of BAY 11-7082 on ET-1 gene expression and ET-1 release, thereby suggesting that NF-κB plays an important role in the regulation of ET-1 production.

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