The Journal of Medical Investigation
Online ISSN : 1349-6867
Print ISSN : 1343-1420
ISSN-L : 1343-1420
Development, Regeneration, and Tissue Engineering of the Glandular Tissue
Branching morphogenesis in the fetal mouse submandibular gland is codependent on growth factors and extracellular matrix
Edward W GresikNoriko KoyamaToru HayashiMasanori Kashimata
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2009 Volume 56 Issue Supplement Pages 228-233

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Abstract

Branching morphogenesis (BrM) is a basic developmental process for the formation of the lung, kidney, and all exocrine glands, including the salivary glands. This process proceeds as follows. An epithelial downgrowth invaginates into underlying mesenchyme, and forms a cleft at its distal end, which is the site of dichotomous branching and elongation; this process of clefting and elongation is repeated many times at the distal ends of the invading epithelium until the desired final extent of branching is reached. The distal ends of the epithelium differentiate into the secretory endpieces, and the elongated segments become the ducts. This presentation is a brief historical review of studies on BrM during the development of the submandibular gland (SMG). J. Med. Invest. 56 Suppl.: 228-233, December, 2009

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© 2009 by The University of Tokushima Faculty of Medicine
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