Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
Enhancing Effect of Carrageenan on the Induction of Rat Colonic Tumors by 1, 2-Dimethylhydrazine and Its Relation to β-Glucuronidase Activities in Feces and Other Tissues
Shoichi ARAKAWAMasanao OKUMURASeiji YAMADAMasao ITOSetsuzo TEJIMA
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JOURNAL FREE ACCESS

1986 Volume 32 Issue 5 Pages 481-485

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Abstract

Since it has been demonstrated that a high level of fat is a dietary factor in the etiology of colon cancer, the effect of carrageenan, a polysaccharide extracted from the red seaweeds, on 1, 2-dimethylhydra-zine-induced colonic tumors in rats fed a semipurified control diet containing an ordinary level of fat was studied. Nevertheless, the enhancing effect of carrageenan on colonic tumors was observed. The rats fed a carrageenan diet had approximately twice the fecal weight compared to the rats fed a control diet. While no significant differences were found in β-glucuronidase activities in colonic mucosa, liver or plasma in the car-rageenan-fed rats and controls, the activity in feces was significantly lower in the carrageenan-fed rats. At least, no β-glucuronidase activity seemed to be related to the tumor-enhancing effect of carrageenan.

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