In a sample of 53 groups of adult males the regularity of spatial variability of hormonal concentrations (testosterone, estradiol, E/T index) was determined. The range of normal biochemical variations of sex hormones in different ethnic-geographical groups was revealed. The hormonal status of different ethnic groups was compared from the point of view of adaptation. The research results present new information on biological individuality and the factors defining it. The hormonal activity optimum depends on ecological factors and serves as a basis for the ecological monitoring of human health.