The present study in Japanese quail was aimed to develop multi-trait genetic selection program for a meat type sire line utilizing the mixed-model methodology. In total, 2000 pedigreed quail were formed the basis of the research where a multi-trait animal model was performed. A flock consisting of a total of 160 families (1 male: 3 female) was developed from the initial flock (base population of sire line), so as to obtain a selection flock sire line. Body weight at 5 weeks of age was chosen as a primary selection criterion in flock. The age at point of inflection derived from Gompertz growth curve, feed conversion ratio between 3 to 5 weeks of age, and carcass yield at 5 week of age were determined as selection criteria. Multi-trait BLUP methodology was carried out for genetic improvement of birds. In flock, 25 percent of males and females with highest breeding value were selected to produce next generation. Genetic parameter estimates, realized genetic parameters, selection responses, and genetic trends were obtained. Significant (P<0.01) selection responses for body weight, age at point of inflection, feed conversion ratio, and carcass yield traits on generations were observed. The results of the study revealed that the negative genetic relationships exhibited between some studied traits had overcame by modern poultry breeding methods such as selection via multi-trait BLUP.