Radiobiological Effectiveness of Laser Accelerated Electrons in Comparison to Electron Beams from a Conventional Linear Accelerator

Lydia LASCHINSKY; Michael BAUMANN; Elke BEYREUTHER; Wolfgang ENGHARDT; Malte KALUZA; Leonhard KARSCH; Elisabeth LESSMANN; Doreen NAUMBURGER; Maria NICOLAI; Christian RICHTER; Roland SAUERBREY; Hans-Peter SCHLENVOIGT; Jörg PAWELKE

doi:10.1269/jrr.11080

Biology

Radiobiological Effectiveness of Laser Accelerated Electrons in Comparison to Electron Beams from a Conventional Linear Accelerator

Lydia LASCHINSKY, Michael BAUMANN, Elke BEYREUTHER, Wolfgang ENGHARDT, Malte KALUZA, Leonhard KARSCH, Elisabeth LESSMANN, Doreen NAUMBURGER, Maria NICOLAI, Christian RICHTER, Roland SAUERBREY, Hans-Peter SCHLENVOIGT, Jörg PAWELKE

Author information

Lydia LASCHINSKY
OncoRay – National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universität
Michael BAUMANN
OncoRay – National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universität
Elke BEYREUTHER
Helmholtz-Zentrum Dresden-Rossendorf
Wolfgang ENGHARDT
OncoRay – National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universität
Helmholtz-Zentrum Dresden-Rossendorf
Malte KALUZA
Institute of Optics and Quantum Electronics, Friedrich-Schiller-University
Leonhard KARSCH
OncoRay – National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universität
Elisabeth LESSMANN
Helmholtz-Zentrum Dresden-Rossendorf
Doreen NAUMBURGER
OncoRay – National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universität
Maria NICOLAI
Institute of Optics and Quantum Electronics, Friedrich-Schiller-University
Christian RICHTER
OncoRay – National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universität
Helmholtz-Zentrum Dresden-Rossendorf
Roland SAUERBREY
Helmholtz-Zentrum Dresden-Rossendorf
Hans-Peter SCHLENVOIGT
Institute of Optics and Quantum Electronics, Friedrich-Schiller-University
Jörg PAWELKE
OncoRay – National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universität
Helmholtz-Zentrum Dresden-Rossendorf

Keywords: Laser particle acceleration, Laser radiotherapy, Cell response to electrons, Pulsed irradiation

JOURNAL OPEN ACCESS

2012 Volume 53 Issue 3 Pages 395-403

DOI https://doi.org/10.1269/jrr.11080

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Abstract

The notable progress in laser particle acceleration technology promises potential medical application in cancer therapy through compact and cost effective laser devices that are suitable for already existing clinics. Previously, consequences on the radiobiological response by laser driven particle beams characterised by an ultra high peak dose rate have to be investigated. Therefore, tumour and non-malignant cells were irradiated with pulsed laser accelerated electrons at the JETI facility for the comparison with continuous electrons of a conventional therapy LINAC. Dose response curves were measured for the biological endpoints clonogenic survival and residual DNA double strand breaks. The overall results show no significant differences in radiobiological response for in vitro cell experiments between laser accelerated pulsed and clinical used electron beams. These first systematic in vitro cell response studies with precise dosimetry to laser driven electron beams represent a first step toward the long term aim of the application of laser accelerated particles in radiotherapy.

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