A case of neonatal alloimmune thrombocytopenia from human platelet antigen 5b incompatibility

Takehiro Serikawa; Yasuhiro Takahashi; Kaya Ichikawa; Ruriko Uemura; Akira Kikuchi; Koichi Takakuwa; Seiichi Sakakibara; Masamichi Matsunaga; Kenichi Tanaka

doi:10.3192/jsirib.24.18

Takehiro Serikawa, Yasuhiro Takahashi, Kaya Ichikawa, Ruriko Uemura, Akira Kikuchi, Koichi Takakuwa, Seiichi Sakakibara, Masamichi Matsunaga, Kenichi Tanaka

Author information

Takehiro Serikawa
Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital
Yasuhiro Takahashi
Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital
Kaya Ichikawa
Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital
Ruriko Uemura
Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital
Akira Kikuchi
Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital
Koichi Takakuwa
Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital
Seiichi Sakakibara
Department of Pediatrics, Niigata University Medical and Dental Hospital
Masamichi Matsunaga
Department of Pediatrics, Niigata University Medical and Dental Hospital
Kenichi Tanaka
Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital

Keywords: alloimmune thrombocytopenia, human-specific platelet antigen, amniocentesis, mixed passive hemagglutination

JOURNAL FREE ACCESS

2009 Volume 24 Issue 1 Pages 18-20

DOI https://doi.org/10.3192/jsirib.24.18

Details

Abstract

Anti-human platelet-specific antigen (HPA) antibody often causes neonatal alloimmune thrombocytopenia (NAIT). The antibody is produced due to the feto-maternal transfusion of incompatible platelets. In this case study, anti-HPA-5b was detected in the serum of a 30-year-old female patient. Using blood or amniotic fluid, the patient's HPA-5 phenotype was determined to be a+b-, whereas those of the husband, son and fetus were a+b+. From these findings, we concluded that there was an incompatibility of maternal and fetal HPA. Cordocentesis was performed at 34 weeks of gestation and the fetal platelet count was sufficient for vaginal delivery. A transfusion of HPA-matched platelet was prepared. The baby was delivered by vaginal delivery and there were no physical signs of thrombocytopenia.

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