Early-Onset Severe Diffuse Alveolar Hemorrhage after Bortezomib Administration Suggestive of Pulmonary Involvement of Myeloma Cells

Yasumasa Sugita; Chikako Ohwada; Yuhei Nagao; Chika Kawajiri; Ryoh Shimizu; Emi Togasaki; Atsuko Yamazaki; Tomoya Muto; Shio Sakai; Yusuke Takeda; Naoya Mimura; Masahiro Takeuchi; Emiko Sakaida; Tohru Iseki; Koutaro Yokote; Chiaki Nakaseko

doi:10.3960/jslrt.55.163

Case Study

Early-Onset Severe Diffuse Alveolar Hemorrhage after Bortezomib Administration Suggestive of Pulmonary Involvement of Myeloma Cells

Yasumasa Sugita, Chikako Ohwada, Yuhei Nagao, Chika Kawajiri, Ryoh Shimizu, Emi Togasaki, Atsuko Yamazaki, Tomoya Muto, Shio Sakai, Yusuke Takeda, Naoya Mimura, Masahiro Takeuchi, Emiko Sakaida, Tohru Iseki, Koutaro Yokote, Chiaki Nakaseko

Author information

Yasumasa Sugita
Department of Hematology, Asahi General Hospital
Chikako Ohwada
Department of Hematology, Chiba University Hospital
Yuhei Nagao
Department of Hematology, Chiba University Hospital
Chika Kawajiri
Department of Hematology, Chiba University Hospital
Ryoh Shimizu
Department of Hematology, Chiba University Hospital
Emi Togasaki
Department of Hematology, Chiba University Hospital
Atsuko Yamazaki
Department of Hematology, Chiba University Hospital
Tomoya Muto
Department of Hematology, Chiba University Hospital
Shio Sakai
Department of Blood Transfusion and Cell Therapy, Chiba University Hospital
Yusuke Takeda
Department of Hematology, Chiba University Hospital
Naoya Mimura
Department of Blood Transfusion and Cell Therapy, Chiba University Hospital
Masahiro Takeuchi
Department of Hematology, Chiba University Hospital
Emiko Sakaida
Department of Hematology, Chiba University Hospital
Tohru Iseki
Department of Blood Transfusion and Cell Therapy, Chiba University Hospital
Koutaro Yokote
Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine
Chiaki Nakaseko
Department of Hematology, Chiba University Hospital

Keywords: multiple myeloma, bortezomib, acute lung injury, diffuse alveolar hemorrhage

JOURNAL FREE ACCESS

2015 Volume 55 Issue 3 Pages 163-168

DOI https://doi.org/10.3960/jslrt.55.163

Details

Abstract

　 Severe acute lung injury is a rare but life-threatening complication associated with bortezomib. We report a patient with multiple myeloma who developed a severe diffuse alveolar hemorrhage (DAH) immediately after the first bortezomib administration. The patient was suspected to have pulmonary involvement of myeloma, which caused DAH after rapidly eradicating myeloma cells in the lungs with bortezomib. Rechallenge with bortezomib was performed without recurrent DAH. In patients with multiple myeloma who manifest abnormal pulmonary shadow, we should be aware of early-onset severe DAH after bortezomib administration, which might be due to pulmonary involvement of myeloma cells. [J Clin Exp Hematop 55(3) : 163-168, 2015]

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