Since fouling generated inside pipes of chemistry plant equipment, shortens “its life”, periodical maintenance such as cleaning or replacement is needed. Therefore, the development of a safe and sanitary method of preventing a corrosion and blockage inside pipes is desired. In this study, a vibration system, composed of a bolt-clamped Langevin transducer and a pipe, was employed to experimentally study the possibility of fouling removal. In the experiment, a flexural vibration was excited in a pipe containing fouling using ultrasonic waves. When the pipe was made to vibrate, with calcium carbonate or starch used as the fouling, it was shown that the fouling was diffused into the air, and except at the node of the flexural vibration, the fouling was removed completely. Also, the result showed that a higher input voltage to the transducer was more effective in removing the fouling.