Silencing of the gene for homeobox protein HOXB13 by  siRNA confers resistance to methylmercury on HEK293 cells

Gi-Wook Hwang; Katsunori Ryoke; Tsutomu Takahashi; Akira Naganuma

doi:10.2131/jts.35.941

Toxicogenomics/proteomics Report

Silencing of the gene for homeobox protein HOXB13 by siRNA confers resistance to methylmercury on HEK293 cells

Gi-Wook Hwang, Katsunori Ryoke, Tsutomu Takahashi, Akira Naganuma

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Keywords: Methylmercury, Homeobox protein, HOXB13, Transcription factor

JOURNAL FREE ACCESS

2010 Volume 35 Issue 6 Pages 941-944

DOI https://doi.org/10.2131/jts.35.941

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Abstract

Methylmercury is an environmental pollutant that causes severe central nervous system disorders. We searched for transcription factors involved in the development of methylmercury toxicity and found that the decreased expression of a homeobox protein, HOXB13, in HEK293 cells conferred strong resistance to methylmercury.

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