Effects of Central Kalimantan Plant Extracts on Intraerythrocytic Babesia gibsoni in Culture

SUBEKI; Hideyuki MATSUURA; Masahiro YAMASAKI; Osamu YAMATO; Yoshimitsu MAEDE; Ken KATAKURA; Mamoru SUZUKI; TRIMURNINGSIH; CHAIRUL; Teruhiko YOSHIHARA

doi:10.1292/jvms.66.871

NOTE

Effects of Central Kalimantan Plant Extracts on Intraerythrocytic Babesia gibsoni in Culture

SUBEKI, Hideyuki MATSUURA, Masahiro YAMASAKI, Osamu YAMATO, Yoshimitsu MAEDE, Ken KATAKURA, Mamoru SUZUKI, TRIMURNINGSIH, CHAIRUL, Teruhiko YOSHIHARA

Author information

SUBEKI
Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
Hideyuki MATSUURA
Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
Masahiro YAMASAKI
Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
Osamu YAMATO
Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
Yoshimitsu MAEDE
Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
Ken KATAKURA
Department of Parasitology, Gunma University School of Medicine
Mamoru SUZUKI
Department of Parasitology, Gunma University School of Medicine
TRIMURNINGSIH
Department of Research and Development for Biology, Indonesian Institute of Sciences
CHAIRUL
Department of Research and Development for Biology, Indonesian Institute of Sciences
Teruhiko YOSHIHARA
Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University

Keywords: antibabesial activity, Babesia gibsoni, Central Kalimantan plant, toxicity

JOURNAL FREE ACCESS

2004 Volume 66 Issue 7 Pages 871-874

DOI https://doi.org/10.1292/jvms.66.871

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Abstract

The inhibitory effects of 45 plant extracts selected from Central Kalimantan, Indonesia on Babesia gibsoni in vitro and their acute toxicity to mice were evaluated. Of these plant extracts studied, Arcangelisia flava, Curcuma zedoaria, Garcinia benthamiana, Lansium domesticum and Peronema canescens were found to have appreciable antibabesial activity with IC₅₀ values from 5.3 to 49.3 μg/ml without acute toxicity in mice at the intraperitoneal dose of 0.7 g/kg of body weight.

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