Characterization of Canine Platelet Activation Induced by Platelet Activating Factor (PAF)

Ryo TSUCHIYA; Yumiko TATSUKI; Satoshi KITAO; Mitsuru FURUICHI; Sakurako NEO; Masaharu HISASUE; Takatsugu YAMADA; Kosaku KOBAYASHI

doi:10.1292/jvms.70.181

Clinical Pathology

Characterization of Canine Platelet Activation Induced by Platelet Activating Factor (PAF)

Ryo TSUCHIYA, Yumiko TATSUKI, Satoshi KITAO, Mitsuru FURUICHI, Sakurako NEO, Masaharu HISASUE, Takatsugu YAMADA, Kosaku KOBAYASHI

Author information

Keywords: canine platelet, inhibitor, platelet activating factor

JOURNAL FREE ACCESS

2008 Volume 70 Issue 2 Pages 181-183

DOI https://doi.org/10.1292/jvms.70.181

Details

Abstract

Characteristics of the signal transduction in Platelet activating factor (PAF)-activated platelets and effects of anti-platelet agents on this response were investigated in vitro for potential therapeutic applications in canine endotoxemia. Blockade of the PAF receptor by a specific blocker has the strongest inhibitive effect on the PAF-induced platelet reactions. The response was also inhibited by either Ca²⁺ channel blockers or prostaglandin E₁.

Corresponding author

Register with J-STAGE for free!