Laboratory Animal Science
Bone morphological analyses in Spontaneously Diabetic Torii (SDT) fatty rats
2015 Volume 77 Issue 10 Pages 1327-1330
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2015 Volume 77 Issue 10 Pages 1327-1330
The Spontaneously Diabetic Torii (SDT) fatty rat, a model for obese type 2 diabetes, shows bone quantitative abnormalities, namely low bone mineral density (BMD). The objective of this study was to evaluate bone morphological changes, in particular identifying the bone qualitative abnormalities, in the SDT fatty rat. Male SDT fatty rats showed increases in total trabecular area and trabecular number and decreases in trabecular thickness in cancellous bones of the proximal tibia, indicating trabecular miniaturization. The SDT fatty rat is useful for investigation of pathophysiological changes in bone quality in diabetic osteoporosis.
Journal of The Japanese Society of Veterinary Science
