Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma

Masaki MICHISHITA; Aya OHTSUKA; Rei NAKAHIRA; Tsuyoshi TAJIMA; Takayuki NAKAGAWA; Nobuo SASAKI; Toshiro ARAI; Kimimasa TAKAHASHI

doi:10.1292/jvms.15-0550

Pharmacology

Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma

Masaki MICHISHITA, Aya OHTSUKA, Rei NAKAHIRA, Tsuyoshi TAJIMA, Takayuki NAKAGAWA, Nobuo SASAKI, Toshiro ARAI, Kimimasa TAKAHASHI

Author information

Masaki MICHISHITA
Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1–7–1 Kyonan-cho, Musashino, Tokyo 180–8602, Japan
Aya OHTSUKA
Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1–7–1 Kyonan-cho, Musashino, Tokyo 180–8602, Japan
Rei NAKAHIRA
Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1–7–1 Kyonan-cho, Musashino, Tokyo 180–8602, Japan
Tsuyoshi TAJIMA
Department of Veterinary Pharmacology, Nippon Veterinary and Life Science University, 1–7–1 Kyonan-cho, Musashino, Tokyo 180–8602, Japan
Takayuki NAKAGAWA
Department of Veterinary Surgery, The University of Tokyo, 1–1–1 Yayoi, Bunkyo, Tokyo 113–8657, Japan
Nobuo SASAKI
Department of Veterinary Surgery, The University of Tokyo, 1–1–1 Yayoi, Bunkyo, Tokyo 113–8657, Japan
Toshiro ARAI
Department of Veterinary Biochemistry, Nippon Veterinary and Life Science University, 1–7–1 Kyonan-cho, Musashino, Tokyo 180–8602, Japan
Kimimasa TAKAHASHI
Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1–7–1 Kyonan-cho, Musashino, Tokyo 180–8602, Japan

Keywords: bevacizumab, feline mammary carcinoma, vascular endothelial growth factor (VEGF), xenograft

JOURNAL FREE ACCESS

2016 Volume 78 Issue 4 Pages 685-689

DOI https://doi.org/10.1292/jvms.15-0550

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Abstract

Feline mammary carcinomas are characterized by rapid progression and metastases. Vascular endothelial growth factor (VEGF) is a key regulator of tumor angiogenesis, proliferation and metastasis. The present study aimed to investigate the effects of a single drug therapy of bevacizumab on a xenograft model of feline mammary carcinoma expressing VEGF protein. Bevacizumab treatment suppressed tumor growth by inhibiting angiogenesis and enhancing apoptosis; however, it did not affect the tumor proliferation index. Thus, bevacizumab had anti-tumor effects on a xenograft model, and this may be useful for the treatment of feline mammary carcinoma.

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