Feasible induction of coronary artery vasospasm occurred during cardiac          catheterization in a microminipig

Suchitra MATSUKURA; Yuji NAKAMURA; Hiroshi OHARA; Xin CAO; Takeshi WADA; Hiroko IZUMI-NAKASEKO; Kentaro ANDO; Yoshikiyo AKASAKA; Atsushi SUGIYAMA

doi:10.1292/jvms.15-0426

Laboratory Animal Science

Feasible induction of coronary artery vasospasm occurred during cardiac catheterization in a microminipig

Suchitra MATSUKURA, Yuji NAKAMURA, Hiroshi OHARA, Xin CAO, Takeshi WADA, Hiroko IZUMI-NAKASEKO, Kentaro ANDO, Yoshikiyo AKASAKA, Atsushi SUGIYAMA

Author information

Suchitra MATSUKURA
Department of Pharmacology, Faculty of Medicine, Toho University, 5–21–16 Omori-nishi, Ota-ku, Tokyo 143–8540, Japan
Yuji NAKAMURA
Department of Pharmacology, Faculty of Medicine, Toho University, 5–21–16 Omori-nishi, Ota-ku, Tokyo 143–8540, Japan
Hiroshi OHARA
Division of Cardiovascular Medicine, Department of Internal Medicine, Faculty of Medicine, Toho University, 6–11–1 Omori-nishi, Ota-ku, Tokyo 143–8541, Japan
Xin CAO
Department of Pharmacology, Faculty of Medicine, Toho University, 5–21–16 Omori-nishi, Ota-ku, Tokyo 143–8540, Japan
Takeshi WADA
Department of Pharmacology, Faculty of Medicine, Toho University, 5–21–16 Omori-nishi, Ota-ku, Tokyo 143–8540, Japan
Hiroko IZUMI-NAKASEKO
Department of Pharmacology, Faculty of Medicine, Toho University, 5–21–16 Omori-nishi, Ota-ku, Tokyo 143–8540, Japan
Kentaro ANDO
Department of Pharmacology, Faculty of Medicine, Toho University, 5–21–16 Omori-nishi, Ota-ku, Tokyo 143–8540, Japan
Yoshikiyo AKASAKA
Department of Pathology, Faculty of Medicine, Toho University, 5–21–16 Omori-nishi, Ota-ku, Tokyo 143–8540, Japan
Atsushi SUGIYAMA
Department of Pharmacology, Faculty of Medicine, Toho University, 5–21–16 Omori-nishi, Ota-ku, Tokyo 143–8540, Japan

Keywords: coronary spastic angina, defibrillator, sudden cardiac death

JOURNAL FREE ACCESS

2016 Volume 78 Issue 5 Pages 873-876

DOI https://doi.org/10.1292/jvms.15-0426

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Abstract

A 14 month-old intact microminipig, weighing 8 kg, showed ST-segment elevation in A-B lead electrocardiogram during cardiac catheterization followed by ventricular tachycardia, which degenerated into ventricular fibrillation. Although a direct current defibrillation of 360 J was applied, ventricular tachycardia re-occurred for another 2 times and the direct defibrillation was repeated. After returning to normal sinus rhythm, a marked ST-segment elevation was still observed on leads II, III and aVF together with a remarkable decrease in contractility of inferior wall. The heart was excised for precise macroscopic and histological examinations, but there was no dissection, embolus or thrombus in the coronary arteries. These findings suggest that right coronary artery vasospasm could have caused the ischemic attack, leading to lethal arrhythmias.

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